| ncRNA name | AKR1B1 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic cataract |
| Species | Rattus norvegicus |
| Tissues/Cell_line | lenses |
| Methods | DNA sequencing, genotyping, RT-PCR, Western blot |
| Expression pattern | associated |
| Functional description | Aldose reductase (AKR1B1), which catalyzes the reduction of glucose to sorbitol and lipid aldehydes to lipid alcohols, has been shown to be involved in secondary diabetic complications including cataractogenesis. Rat lenses obtained from AKR1B1 knockdown rats were resistant to high glucose-induced lens opacification as compared to wild-type (WT) rat lenses. |
| PubMed ID | 21376710 |
| Year | 2011 |
| Title | Aldose reductase deficiency protects sugar-induced lens opacification in rats. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.